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OBC副主编精选论文: 南京大学·王欢教授

  • 2026-03-25 13:18:43
OBC副主编精选论文: 南京大学·王欢教授

英国皇家化学会出版的有机化学领域期刊 Organic & Biomolecular Chemistry (OBC) 发表有机化学领域的高影响力研究论文和综述。

近日，期刊副主编、南京大学王欢教授精选出多篇 OBC 论文，欢迎下滑查看！

王欢教授

2005 年本科毕业于北京大学化学与分子工程学院，2010 年于马里兰大学化学与生物化学系取得博士学位。在伊利诺伊大学香槟分校化学系从事 4 年的博士后研究后，于 2014 年加入南京大学化学化工学院，并于 2023 年起获得国家自然科学基金委杰出青年基金支持。
课题组聚焦生物活性环肽的化学生物学研究，结合生物化学和合成化学等技术手段，致力于发展多肽大环化的化学方法和酶学工具。

更多详情，请访问课题组网站：hysz.nju.edu.cn/wanghuan

王欢教授精选 OBC 论文

  • Histidine-bridged cyclic peptide natural products: isolation, biosynthesis and synthetic studies

    Pascal M. Engelhardt, Robert Keyzers* (🇳🇿 惠灵顿维多利亚大学) & Margaret A. Brimble* (🇳🇿 奥克兰大学)

    Org. Biomol. Chem., 2024, 22, 8374-8396 ‍
    https://doi.org/10.1039/D4OB01259C

    王欢教授点评：  

    这篇及时的综述总结了四十年来关于组氨酸桥联大环肽的研究成果，重点介绍了它们独特的交联化学性质、多样化的生物合成来源以及新兴的生物活性。该文汇总了结构、生物合成和合成等方面的观点，为未来探索和研究这类尚未被充分开发的肽类天然产物提供了全面的参考资料。

  • Ag(I)-promoted fragment coupling of peptide thioamides

    Varsha J. Thombare, Carlie L. Charron & Craig A. Hutton* (🇦🇺 墨尔本大学)

    Org. Biomol. Chem., 2025, 23, 1995-1999 ‍https://doi.org/10.1039/D4OB01906G 

    王欢教授点评：

    这项工作提出了一种概念上独特的片段偶联策略，利用 Ag(I) 介导的异酰亚胺 (isoimide) 生成反应，无需传统的肽偶联试剂即可得到天然酰胺键。该方法能够高效地实现溶液相和固相偶联，是对现有基于 NCL 方法的有效补充，并有望被应用于合成含天冬酰亚胺的复杂肽序列。

  • Frog farnesyl pyrophosphate synthases and their role as non-canonical terpene synthases for bisabolane sesquiterpenes

    Kexin Yang, Houchao Xu, Miguel Vences, Andolalao Rakotoarison, Stefan Schulz & Jeroen S. Dickschat* (🇩🇪 波恩大学) 

    Org. Biomol. Chem., 2025, 23, 7940-7945 ‍https://doi.org/10.1039/D5OB01139F

    王欢教授点评：  

    本研究发现蛙类的法呢基焦磷酸合酶 (farnesyl pyrophosphate synthase, FPPS) 同源物能够催化 (2Z,6E)-FPP 发生意想不到的环化反应，生成双环倍半萜类化合物，从而揭示出多种 FPPS 酶所具有的一种潜在能力。该发现拓展了我们对高等动物萜类生物合成的理解，并启发了关于酶进化、底物混杂性以及挥发性信号分子生理意义等基础性问题。

期刊简介

Organic synthesis, supramolecular chemistry, chemical biology and more

rsc.li/obc

Org. Biomol. Chem.

2-年影响因子*
2.7分
5-年影响因子*
2.9分
JCR 分区*
Q2 化学-有机
CiteScore 分†
5.2分
中位一审周期‡
19天

Organic & Biomolecular Chemistry (OBC) 发表有机化学领域的高影响力研究论文和综述，特别是全合成、合成方法学或物理和理论有机化学中新发展的方法或是对原有方法的显著改进，以及对化学生物学、催化、超分子和大分子化学、有机材料、理论化学、药物化学或天然产物具有重大意义的有机化学或分子设计研究进展。

Chair

  • Anthony Davis🇬🇧 布里斯托大学

Associate editors

  • Jeroen Dickschat🇩🇪 波恩大学

  • Katrina Jolliffe🇦🇺 悉尼大学

  • Motomu Kanai🇯🇵 东京大学

  • Xiaohua Liu (刘小华)🇨🇳 四川大学

  • Santanu Mukherjee🇮🇳 班加罗尔印度科学研究院

  • Scott Silverman🇺🇸 伊利诺伊大学香槟分校

  • Cristina Trujillo🇬🇧 曼彻斯特大学

  • Huan Wang (王欢)🇨🇳 南京大学

Editorial board members

  • S.S.V Ramasastry🇮🇳 莫哈利印度科学教育与研究所

  • Judy I-Chia Wu🇺🇸 休斯顿大学

* 2024 Journal Citation Reports (Clarivate, 2025)† CiteScore 2024 by Elsevier‡ 中位数，仅统计进入同行评审阶段的稿件

欢迎联系我们发布论文报道📧 RSCChina@rsc.org
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  1. CONNECT:[ UseTime:0.000394s ] mysql:host=127.0.0.1;port=3306;dbname=b460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000591s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.001216s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000273s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000521s ]
  6. SELECT * FROM `set` [ RunTime:0.004475s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000647s ]
  8. SELECT * FROM `article` WHERE `id` = 480831 LIMIT 1 [ RunTime:0.005711s ]
  9. UPDATE `article` SET `lasttime` = 1775558529 WHERE `id` = 480831 [ RunTime:0.015653s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000302s ]
  11. SELECT * FROM `article` WHERE `id` < 480831 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000427s ]
  12. SELECT * FROM `article` WHERE `id` > 480831 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000388s ]
  13. SELECT * FROM `article` WHERE `id` < 480831 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.009041s ]
  14. SELECT * FROM `article` WHERE `id` < 480831 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.010530s ]
  15. SELECT * FROM `article` WHERE `id` < 480831 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.032505s ]
0.171752s