当前位置：首页>南京>南京大学医学院附属金陵医院发表论文被质疑存在图像重复及跨篇挪用问题

南京大学医学院附属金陵医院发表论文被质疑存在图像重复及跨篇挪用问题

  • 2026-03-26 01:54:52
南京大学医学院附属金陵医院发表论文被质疑存在图像重复及跨篇挪用问题

以组蛋白去乙酰化酶抑制剂（HDACis）为基础的疗法出现耐药，是导致鼻咽癌患者预后不良的重要因素之一。目前，HDACis 耐药的具体机制尚未明确。已有研究显示，长链非编码 RNA（LncRNAs）和微小 RNA（miRNAs）的表达异常，可在多种癌症的耐药过程中起促进或抑制作用。

2020年，南京大学医学院附属金陵医院研究团队在期刊 Aging 上发表了题为“LncRNA NEAT1/miR-129/Bcl-2 signaling axis contributes to HDAC inhibitor tolerance in nasopharyngeal cancer”的论文。

该研究指出，NEAT1 在鼻咽癌组织中表达上调，并通过调控 miR-129/Bcl-2 信号轴增强癌细胞对 SAHA 的耐药性，这为鼻咽癌治疗提供了新的潜在靶点。

近期，有用户在查重系统内指出，该论文可能涉及多处图像重复问题。

具体包括：

  1. 图 6E 中，不同处理组的细胞核染色图像显示高度相似；

  2. 部分图像与先前发表于《Molecular Therapy》期刊的论文中的图片重合；

  3. 一张蛋白质印迹（Western blot）实验图片疑似重复使用自 2014 年《Nature Communications》期刊上发表的一篇论文（DOI: 10.1038/ncomms6637）。

截至目前，作者尚未就以上质疑公开回应。

参考消息：

https://www.aging-us.com/article/103427/text

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  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000334s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000274s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000475s ]
  6. SELECT * FROM `set` [ RunTime:0.000205s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000598s ]
  8. SELECT * FROM `article` WHERE `id` = 486722 LIMIT 1 [ RunTime:0.000440s ]
  9. UPDATE `article` SET `lasttime` = 1775314067 WHERE `id` = 486722 [ RunTime:0.000901s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000214s ]
  11. SELECT * FROM `article` WHERE `id` < 486722 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000425s ]
  12. SELECT * FROM `article` WHERE `id` > 486722 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000361s ]
  13. SELECT * FROM `article` WHERE `id` < 486722 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000630s ]
  14. SELECT * FROM `article` WHERE `id` < 486722 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.000459s ]
  15. SELECT * FROM `article` WHERE `id` < 486722 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.000676s ]
0.085728s