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IF=38.7!博士毕业南京医科大学,广州医科大学教授发表最新研究成果

  • 2026-02-04 20:08:09
IF=38.7!博士毕业南京医科大学,广州医科大学教授发表最新研究成果
2026 年 1 月 30 日，广州医科大学基础医学院徐益鸣教授课题组在心血管领域顶级期刊Circulation上发表了题为“DAPK2 Regulates PKM2 Phosphorylation at Threonine 45 to Facilitate Disturbed Flow–Induced Atherosclerosis”的研究论文。该研究首次鉴定DAPK2(死亡相关蛋白激酶2)为对D-flow高度敏感的内皮激酶，并系统阐明其在湍流诱导的内皮炎症与动脉粥样硬化发生中的关键作用及分子机制。
具体而言，该研究系统揭示了D-flow通过DAPK2介导PKM2T45磷酸化及核转位，驱动内皮炎性激活并促进AS发生的分子机制，确立了DAPK2作为血流力学信号与内皮炎症反应之间关键调控节点的作用。这一发现为深入理解AS的发病机制，并探索基于血流动力学的治疗策略提供了重要理论基础和潜在药理靶点。
原文链接：
https://doi.org/10.1161/CIRCULATIONAHA.125.075951
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  1. CONNECT:[ UseTime:0.000546s ] mysql:host=127.0.0.1;port=3306;dbname=b460;charset=utf8mb4
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  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000258s ]
  11. SELECT * FROM `article` WHERE `id` < 474273 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.002430s ]
  12. SELECT * FROM `article` WHERE `id` > 474273 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.003669s ]
  13. SELECT * FROM `article` WHERE `id` < 474273 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.003822s ]
  14. SELECT * FROM `article` WHERE `id` < 474273 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.010403s ]
  15. SELECT * FROM `article` WHERE `id` < 474273 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.014596s ]
0.127254s