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学术前沿 | 南京大学先进制造学院简小华最新Chem. Eng. J.:集成式可穿戴多功能超声治疗贴片

  • 2026-05-09 13:33:06
学术前沿 | 南京大学先进制造学院简小华最新Chem. Eng. J.:集成式可穿戴多功能超声治疗贴片

针对传统超声治疗仪器体积大、重量沉、操作要求复杂,无法实现居家长期治疗的临床痛点,以及现有穿戴式超声在便携性、系统集成及治疗方面的技术不足,南京大学先进制造学院联合南京医科大学研发了全球首个兼具极致轻量化与物理精准调控的“集成式可穿戴多功能超声治疗贴片”。团队针对糖尿病足等慢性伤口“难愈合、深层感染难清除”的医学难题,成功实现了微型无线功率超声贴片(<10g)与压电纳米复合智能水凝胶的系统级耦合。相关研究成果以“A Wearable Sonodynamic Therapy Platform with a Piezocatalytic Nanocomposite Hydrogel for Diabetic Wound Healing”为题,发表于Chemical Engineering Journal。南京大学先进制造学院2022级博士研究生林金玉和李鸿超为论文共同第一作者,南京大学简小华特聘研究员、曹文武教授以及南京医科大学袁华教授为共同通讯作者。

研究背景
慢性糖尿病伤口因持续细菌感染、炎症失调和血管生成障碍而难以愈合,给患者带来沉重的医疗负担。传统银基伤口敷料(如Aquacel Ag、Acticoat)依赖被动的渗出液吸收机制,银离子释放缓慢且不可控,对严重生物膜感染的疗效有限。近年来,水凝胶基伤口敷料因其3D多孔结构和保湿特性受到关注,但单纯的水凝胶缺乏主动抗菌能力,甚至可能为细菌增殖提供营养环境。光动力疗法等光触发手段虽能实现主动刺激,但组织穿透深度不足(< 3 mm),难以作用于深层缺血创面。相比之下,声动力疗法(SDT)利用1.0 MHz超声可穿透软组织2-5 cm,通过压电材料在机械应力下产生局部活性氧(Reactive Oxygen Species, ROS),兼具抗菌与促再生功能,为慢性伤口治疗提供了新的策略方向。
研究亮点
本研究针对慢性糖尿病伤口因持续细菌感染、炎症失调和血管生成障碍而难以愈合的临床难题,突破了传统银基敷料被动抗菌效果有限、光动力疗法组织穿透不足以及临床超声设备笨重不便携的瓶颈。团队基于压电催化原理,选用钛酸钡(BTO)作为高效声敏剂,通过银纳米颗粒构建肖特基结增强电荷分离与抗菌活性,并以聚多巴胺修饰提升分散稳定性,将其嵌入明胶基水凝胶构建超声响应性治疗平台。在此基础上,开发了直径约20 mm、重量低于10 g的全球最小功率型可穿戴超声贴片,采用低成本石墨烯纽扣电池实现一周续航的“无感穿戴”;通过精准标定纳米材料空化阈值(0.53 MPa)反向指导器件设计,使输出声压(~0.6 MPa / 1.5 W/cm²)既能高效激发声动力效应又严格符合美国食品药品监督管理局(FDA)安全标准;同时利用水凝胶作为声学耦合剂与智能药物储库,实现超声触发下ROSAg⁺的按需脉冲释放,杀菌率达99.6%以上,为慢性伤口的家庭化、个性化智能治疗提供了新范式。
面向场景
该可穿戴声动力治疗平台具有三大核心应用场景:其一,为糖尿病足溃疡、严重褥疮等需长周期治疗的慢性伤口患者提供无束缚居家理疗方案,患者可在日常自由活动中完成高效杀菌与促愈合治疗,无需频繁往返医院;其二,通过内置蓝牙模块与智能手机应用直连,支持医生或患者依据伤口感染期、组织重塑期等不同愈合阶段,实时无创地进行“阶梯式”超声参数调节,实现个性化数字医疗;其三,凭借1.0 MHz功率超声可实现2-5 cm的深层组织穿透,相较于传统光动力疗法(< 3 mm)可有效清除深层缺血病灶及顽固性生物被膜感染,拓展了物理治疗的适用范围。
图1 用于糖尿病伤口愈合的可穿戴SDT平台示意图
模块与性能
该平台由三大核心模块构成:硬件层面,基于氮化镓高频驱动电路与PZT-4压电陶瓷的微型无线功率超声贴片,集成微控制器与L-C谐振网络,在极小体积内解决了传统大功率超声设备的散热难题,实现了低功耗下的高效声能转换与深层声波传递;耗材层面,PDA@BTO-Ag/Gl/GelMA复合水凝胶创新性地以多巴胺作为“绿色还原剂”,在钛酸钡表面原位还原锚定银纳米颗粒,其超薄聚多巴胺仿生涂层既解决了纳米颗粒团聚问题,又赋予材料极高生物相容性,消除了重金属离子全身毒性隐患;活体疗效系统验证方面,在活体糖尿病大鼠全层皮肤缺损模型中,平台第9天即实现95.8%创面闭合率、第15天达100%愈合,显著超越现有前沿敷料,且通过RNA-seq转录组学与Western Blot蛋白印迹技术从基因到蛋白层面,证实其能有效下调促炎因子IL-6、上调促血管生成因子,重塑糖尿病伤口微环境。
图2 可穿戴超声贴片的设计与制备
图3 体内抗菌与伤口愈合性能
总结与展望
本研究构建的可穿戴声动力治疗平台,通过压电纳米材料与微型超声器件的协同设计,实现了慢性伤口从"医院集中治疗"向"家庭自主管理"的范式转变。其核心价值在于以物理机制驱动工程优化,为可穿戴医疗设备的精准化、安全化提供了可复用的方法论。未来随着压电材料体系与超声驱动电路的持续微型化,该平台有望从体表伤口向深部组织干预拓展,成为泛医学声疗的通用技术底座;同时,结合AIoT与多模态传感技术,将推动慢病管理从"定期就医"迈向"实时监测",最终实现"诊疗一体化"的数字医疗新生态。
论文链接:
https://doi.org/10.1016/j.cej.2026.176299
点击文末“阅读原文”可直接访问

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    文章来源 | 简小华课题组

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  1. CONNECT:[ UseTime:0.001046s ] mysql:host=127.0.0.1;port=3306;dbname=b460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000936s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000313s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000240s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000590s ]
  6. SELECT * FROM `set` [ RunTime:0.000223s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000604s ]
  8. SELECT * FROM `article` WHERE `id` = 541432 LIMIT 1 [ RunTime:0.000485s ]
  9. UPDATE `article` SET `lasttime` = 1779366224 WHERE `id` = 541432 [ RunTime:0.002377s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000272s ]
  11. SELECT * FROM `article` WHERE `id` < 541432 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000432s ]
  12. SELECT * FROM `article` WHERE `id` > 541432 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000349s ]
  13. SELECT * FROM `article` WHERE `id` < 541432 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000746s ]
  14. SELECT * FROM `article` WHERE `id` < 541432 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.000905s ]
  15. SELECT * FROM `article` WHERE `id` < 541432 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.000649s ]
0.160684s