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燕山大学赵阳&南京大学赵伟伟‖【Anal. Chem.】自供电有机光电电化学晶体管用于恩诺沙星检测

  • 2026-04-01 16:12:51
燕山大学赵阳&南京大学赵伟伟‖【Anal. Chem.】自供电有机光电电化学晶体管用于恩诺沙星检测

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介绍 /Introduction

有机光电化学晶体管(OPECT)在生物分析领域具有巨大潜力,但其应用受到双电压要求的限制。在此,燕山大学赵阳和南京大学赵伟伟等人构建了一种由 Bi-MOF@CdS@Au/DNA 控制的自供电 OPECT,用于恩诺沙星(ENR)的检测,通过在源极和漏极电极之间集成太阳能电池来实现。ENR 的存在会与适配体发生特异性结合,从而导致适配体从电极表面解离,进而提高电子转移效率。这提高了光生门电压,并促进了阳离子迁移,从而导致通道电流(IDS)显著降低。该平台表现出良好的分析能力,检测范围从 100 纳克/毫升到 100 微克/毫升(R2 = 0.993),检测限为 0.568 纳克/毫升(S/N = 3)。这项工作表明,自供电 OPECT 为环境监测应用提供了一个有前景的平台。
相关成果以 “ Self-Powered Organic Photoelectrochemical Transistor Detection” 为题发表在《Anal. Chem. 
全文速递燕山大学赵阳&南京大学赵伟伟‖Anal.Chem.自供电有机光电电化学晶体管用于恩诺沙星检测.pdf

研究图/Introduction

Figure 1. (A) Schematic of the ENR detection. (B) The H-cell-supported self-powered OPECT system. (C) Operation rationale of the selfpowered OPECT system.

Figure 2. (A) Synthetic process of Bi-MOF. TEM images of Bi-MOF (B) and Bi-MOF@CdS@Au (C). (D) HRTEM image and EDS mapping (E) of Bi-MOF@CdS@Au. (F) XRD spectra of Bi-MOF and Bi-MOF@CdS@Au. (G) XPS spectra of Bi-MOF, Bi-MOF@CdS, and Bi-MOF@CdS@ Au. (H) FTIR spectra of H3BTC, Bi-MOF, and Bi-MOF@CdS@Au.

Figure 3. (A) UV-vis absorption spectra, (B) Tauc plots and VB-XPS, and (C) survey spectra of Bi-MOF and Bi-MOF@CdS@Au. (D) Photoelectric signal response of Bi-MOF, CdS, Bi-MOF@CdS, and Bi-MOF@CdS@Au. (E) EIS Nyquist plots of Bi-MOF and Bi-MOF@CdS@Au. (F) Photoelectric charge transfer mechanism of Bi-MOF@CdS@Au.

Figure 4. (A) The voltage provided by solar panels with the intensity of light. (B) Variation of channel current during five consecutive on-off illumination cycles of the solar panel. (C) Transfer characteristics under different light intensities. (D) Transconductance evolution under different light intensities. (E) The time-dependent transient IGS and IDS responses. (F) The corresponding current gain. (G) IDS-VGS curves for ENR without (solid line) and with (dashed line) light processing. (H) IDS response for ENR. (I) Potential redistribution of the OPECT system for ENR.
Figure 5. (A) IDS responses to ENR with different concentrations. (B) The calibration curves (n = 3) to ENR. (C) The stability test to ENR (100 μg/mL). (D) The selectivity test: 100 μg/mL tetracycline, 100 μg/mL chloramphenicol, 100 μg/mL norfloxacin, 100 μg/mL ciprofloxacin, 100 μg/mL tobramycin, and 100 μg/mL enrofloxacin (n = 3).

结论 /Conclusion

总之,我们开发了一种自供电的 OPECT 系统,该系统克服了传统 OPECT 设备中固有的双电压限制。BiMOF@CdS@Au 三元异质结构的合理设计有效地解决了电荷复合问题,同时促进了光能吸收,从而显著提高了分析性能。在栅极界面处的 ENR-适配体识别导致了敏感的栅极电位调制,通过 OPECT 的高导通电阻放大了这一效应,产生了可测量的 IDS 响应,用于超灵敏检测,最低检测水平可达 0.568 pg/mL。这种自供电的 OPECT 有效地缓解了双电压驱动系统所存在的限制,有望成为先进生物电子检测的通用解决方案。

文献信息 /Literature information

Self-Powered Organic Photoelectrochemical Transistor DetectionChunwang Chai, Yang Zhao,Hanxiao He, Yuan-Cheng Zhu, Yazhou Wang, Hui-Min Jia, and Wei-Wei Zhao*原文链接:https://doi.org/10.1021/acs.analchem.5c06716

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  1. CONNECT:[ UseTime:0.000481s ] mysql:host=127.0.0.1;port=3306;dbname=b460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000702s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000321s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.005138s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000831s ]
  6. SELECT * FROM `set` [ RunTime:0.007741s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000817s ]
  8. SELECT * FROM `article` WHERE `id` = 505628 LIMIT 1 [ RunTime:0.000602s ]
  9. UPDATE `article` SET `lasttime` = 1775116128 WHERE `id` = 505628 [ RunTime:0.014584s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.003808s ]
  11. SELECT * FROM `article` WHERE `id` < 505628 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000442s ]
  12. SELECT * FROM `article` WHERE `id` > 505628 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000530s ]
  13. SELECT * FROM `article` WHERE `id` < 505628 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000865s ]
  14. SELECT * FROM `article` WHERE `id` < 505628 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.002555s ]
  15. SELECT * FROM `article` WHERE `id` < 505628 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.002860s ]
0.112148s