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南京大学医学院:宁夏枸杞如何逆转卵巢衰老?

  • 2026-04-29 08:32:04
南京大学医学院:宁夏枸杞如何逆转卵巢衰老?

随着年龄增长,女性生育力的下降是一个不可回避的生物学难题。其核心在于卵母细胞质量的恶化与卵巢微环境的衰退。近日,由南京大学医学院附属鼓楼医院生殖医学中心主导,联合南京医科大学、南京大学和南京师范大学的多学科团队发表于《Journal of Ethnopharmacology》上题为“Supplementation with Lycium barbarum glycopeptide (LbGp) rescues the quality of aged oocytes”的研究表明,源自传统中药枸杞的活性成分——枸杞糖肽(LbGp)通过“修复内部线粒体”与“重塑外部微环境”的双重机制,显著改善老化卵母细胞的质量。

这项研究不仅揭示了中医药现代化的科学内涵,更为高龄女性的生育力保护提供了潜在的天然策略。
研究所用的枸杞糖肽(LbGp)来自中宁,由宁夏天仁枸杞生物科技股份有限公司提供。

生殖衰老困境:当卵母细胞遭遇“时光侵蚀”,LbGp 如何破局?

女性生殖衰老的本质,是细胞内部的能量危机与外部环境的炎症风暴。老化卵母细胞主要面临三大挑战:线粒体功能障碍导致ATP供应不足;活性氧(ROS)大量堆积,引发DNA损伤;卵巢微环境恶化,支持卵泡发育的颗粒细胞减少,促炎性免疫细胞增多。
传统的干预手段往往难以同时兼顾这些复杂的病理变化。而这项研究通过自然衰老小鼠模型,系统评估了枸杞糖肽(LbGp)的干预效果,发现其展现出了“内外兼修”能力。

1、LbGp的内部修复机制:重启线粒体引擎,清除氧化损伤

蛋白质组学分析显示,LbGp显著激活了PPAR信号通路,这条关键代谢通路的激活带来了以下改变:老化卵母细胞中线粒体膜电位显著恢复,数量和活性增加;过量活性氧被有效清除;胚胎发育至囊胚阶段的比例明显优于未治疗组。
图1(ROS检测)
图1注释:衰老组(Aged)卵母细胞呈现强烈的绿色荧光,代表活性氧(ROS)爆表;而LbGp处理组绿色荧光显著减弱,说明氧化压力被大幅缓解。
图2(线粒体膜电位)
图2注释:利用JC-1染料,健康线粒体发红光,受损线粒体发绿光。衰老组红光微弱(红/绿比值低),显示“发电厂”停摆;LbGp组红光恢复,证明线粒体膜电位重建,能量供应恢复正常。
图3(DNA损伤)
图3注释:绿色的γ-H2AX焦点代表DNA双链断裂。衰老组满布绿点,而LbGp组绿点稀疏

2、LbGp 的外部重塑策略:优化卵巢微环境,重建细胞通讯

如果说卵母细胞是“种子”,那么卵巢微环境就是“土壤”。单细胞测序技术揭示了LbGp对卵巢微环境的调节作用。研究发现,衰老导致颗粒细胞比例大幅下降,促炎性免疫细胞比例异常升高。LbGp干预后,颗粒细胞比例显著回升,免疫细胞比例下降,卵巢恢复了更年轻的细胞生态结构。同时,衰老切断了细胞间的“对话”,尤其是血栓反应蛋白(THBS)介导的信号通路几乎崩溃,而LbGp成功修复了这一通讯网络,为卵母细胞创造了更健康的发育环境。
图4(细胞组成逆转)
图4注释:柱状图清晰显示,衰老导致支持性的颗粒细胞(蓝色部分)比例从年轻组的36.5%骤降至19.4%,而有害的免疫细胞比例上升。LbGp干预后,颗粒细胞比例显著回升,免疫细胞比例下降,细胞生态结构重回年轻化。
图5(通讯网络修复 )
图5注释:圆圈连线图展示了细胞间的信号交流。衰老组中,关键的THBS信号通路(负责细胞与基质相互作用)连线稀疏甚至断裂;而在LbGp组中,该网络的连接强度显著恢复,意味着细胞间重新建立了有效的“对话”机制,协同支持卵泡发育。
这一发现表明LbGp通过重塑细胞组成和修复细胞间通讯,为卵母细胞创造了一个健康、低炎的发育环境。

LbGp引领“药食同源”的生殖抗衰新范式

这项研究的价值不仅在于发现了一种潜在的抗衰老分子,也体现了研究范式的创新:整合蛋白质组学和单细胞测序技术,从“细胞内代谢”到“组织微环境”进行全景式解析,完整揭示了LbGp的作用机制。枸杞作为传统的滋补佳品,其活性成分LbGp被证实具有明确的药理作用,为中医药现代化提供了科学依据。鉴于LbGp在改善卵母细胞质量和胚胎发育潜力方面的效果,未来有望开发出基于枸杞糖肽的膳食补充剂或辅助治疗手段,为高龄女性、卵巢功能减退患者提供新的干预选择。
衰老虽不可逆,但科学的干预可以延缓其进程。这项研究表明,枸杞糖肽(LbGp)通过“内外兼修”——既修复细胞内部的能量工厂,又重塑外部的生存土壤,我们有可能为生命延续争取更多时间与质量。
原文链接:https://doi.org/10.1016/j.jep.2026.121318。
注:(文中图片均来自原论文,已简化注释以便理解)
欢迎转发,让更多人了解科学前沿!
特别申明:“本文内容均源自权威科研文献,仅作学术交流,不涉及任何产品功效宣传。”

编辑:李玲

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  1. CONNECT:[ UseTime:0.000825s ] mysql:host=127.0.0.1;port=3306;dbname=b460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.001268s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000531s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000786s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.001094s ]
  6. SELECT * FROM `set` [ RunTime:0.014819s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.001426s ]
  8. SELECT * FROM `article` WHERE `id` = 517683 LIMIT 1 [ RunTime:0.007564s ]
  9. UPDATE `article` SET `lasttime` = 1777457778 WHERE `id` = 517683 [ RunTime:0.008437s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000639s ]
  11. SELECT * FROM `article` WHERE `id` < 517683 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000978s ]
  12. SELECT * FROM `article` WHERE `id` > 517683 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000881s ]
  13. SELECT * FROM `article` WHERE `id` < 517683 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.002509s ]
  14. SELECT * FROM `article` WHERE `id` < 517683 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001748s ]
  15. SELECT * FROM `article` WHERE `id` < 517683 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.001599s ]
0.130316s