当前位置：首页>南京>缓解肝脂肪变性!南京大学/安徽医科大学第一附属医院合作发文:预防脂肪性肝病有前景的靶点

缓解肝脂肪变性!南京大学/安徽医科大学第一附属医院合作发文:预防脂肪性肝病有前景的靶点

  • 2026-05-12 06:14:08
缓解肝脂肪变性!南京大学/安徽医科大学第一附属医院合作发文:预防脂肪性肝病有前景的靶点

创新多组学队列研究学术论坛

近日，南京大学/安徽医科大学第一附属医院研究团队合作共同在期刊《Advanced Science》上发表了研究论文，题为“Gut Mycobiota-Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction-Associated Steatotic Liver Disease”，本研究证明了（CARD9）的缺乏，一种微生物群识别受体的衔接蛋白，以肠道真菌依赖的方式加剧了高脂饮食（HFD）诱导的非酒精性脂肪性肝病（MASLD）。CARD9 缺乏减少了酿酒酵母（S. cerevisiae）的丰度，而酿酒酵母是一种可缓解 MASLD 进展的益生菌。酿酒酵母通过 Toll 样受体 1（TLR1）显著增加了肠道中（5-HIAA）的丰度，从而减轻了小鼠体重，并通过“肠-肝”轴缓解了 MASLD 表型。特别是，5-HIAA 直接与芳烃受体（AhR）结合并刺激其核转位，随后通过（CPT1A）和（ACOX1）的转录激活诱导脂肪酸氧化。MASLD 患者表现出 S. cerevisiae 和 5-HIAA 水平降低，而 S. cerevisiae 能有效减轻 MASLD 患者的肝脂肪变性并改善其葡萄糖稳态。总之，本研究发现了一条新的真菌 - S. cerevisiae 通路。酿酒酵母可刺激肠道 5-羟吲哚乙酸（5-HIAA）的生成，并表明酿酒酵母和 5-HIAA 可能会减缓非酒精性脂肪性肝病（MASLD）的进展，这表明依赖真菌群的肠肝轴是预防非酒精性脂肪性肝病的一个有前景的目标。

代谢功能障碍相关脂肪性肝病（MASLD）：特征、诱因及研究意义

 01 

代谢功能障碍相关脂肪性肝病（MASLD）被认为是一种代谢综合征，在肥胖和 2 型糖尿病患者中极为常见。其特征为脂肪变性，表现为超过 5%的肝细胞中甘油三酯（TG）蓄积，且在无酒精摄入的情况下发生。遗传因素、代谢因素以及肠道菌群失调在 MASLD 的发展中起着重要作用。因此，阐明 MASLD 的发病机制可为临床治疗提供理论依据。

酿酒酵母补充剂可有效改善 MASLD 患者的肝脂肪变性

 02 

为了在临床中验证发现，研究人员首先从 MASLD 患者那里收集粪便进行 ITS 测序。主成分分析（PCA）表明，健康个体和 MASLD 患者的真菌群落存在显著差异。为了探究肠道真菌群落组成的变化，研究人员评估了不同组中主要分类群的相对比例。在属水平上，MASLD 患者中酵母属（Saccharomyces）有所减少。在种水平上，MASLD 患者中酿酒酵母（S. cerevisiae）显著减少，粪便中酿酒酵母的检测结果也证实了这一点。研究人员还测量了血清和肝脏中的 5-羟吲哚乙酸（5-HIAA）水平，发现与健康个体相比，MASLD 患者中该水平降低。此外，相关性分析表明，肝脏中 5-HIAA 的含量与血浆甘油三酯（TG）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆固醇（TC）水平以及 MASLD 活动评分呈负相关。另外，研究人员开展了一项随机、双盲临床试验，以探究酿酒酵母对非酒精性脂肪性肝病（MASLD）患者的疗效。与安慰剂治疗相比，接受 8 周酿酒酵母治疗的 MASLD 患者血清 FBG、TC、LDL、ALT 和 AST 水平降低，体重也呈下降趋势。与这一结果一致的是，通过超声衰减分析（USAT）和磁共振成像质子密度脂肪分数（MRI-PDFF）观察到，酿酒酵母治疗后肝脏脂肪含量减少。总之，结果表明肠道真菌酿酒酵母通过刺激肠道（5-HIAA）的生成来减轻 MASLD 的进展，其机制在于增强脂肪酸氧化，这表明依赖真菌群的肠肝轴是预防 MASLD 的一个有前景的靶点。

酿酒酵母补充剂有效改善了非酒精性脂肪性肝病患者的肝脂肪变性

结论

 03

总之，本研究揭示了共生真菌群通过“肠 - 肝轴”对非酒精性脂肪性肝病进展的调节作用，并初步表明酿酒酵母和色氨酸代谢途径的分解代谢产物 5 - HIAA可作为恢复肝脏脂质稳态的新疗法。

参考资料：

https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202514830

免费论坛

创新多组学队列研究学术论坛

干细胞前沿创新与临床转化研讨会

第八届上海国际癌症大会

第二届西部单细胞与空间组学论坛

【关于投稿】

转化医学网（360zhyx.com）是转化医学核心门户，旨在推动基础研究、临床诊疗和产业的发展，核心内容涵盖组学、检验、免疫、肿瘤、心血管、糖尿病等。如您有最新的研究内容发表，欢迎联系我们进行免费报道（公众号菜单栏-在线客服联系），我们的理念：内容创造价值，转化铸就未来！

转化医学网（360zhyx.com）发布的文章旨在介绍前沿医学研究进展，不能作为治疗方案使用；如需获得健康指导，请至正规医院就诊。

责任声明：本稿件如有错误之处，敬请联系转化医学网客服进行修改事宜！

微信号：zhuanhuayixue

★ 3月份热门内容 ★

01

宋尔卫院士领衔！新型ADC药物1期临床试验结果发布：展现出显著且持久的抗肿瘤活性及可控的安全性，为晚期实体瘤患者带来持久临床获益

02

Science重磅发布！科学家绘制全球首张全胚胎、亚细胞分辨率、时空动态图谱，揭示生命构建的底层密码

03

粪菌移植治疗帕金森病新突破！中山大学附属第一医院王雪晶/丁雪冰/曾进胜&美国贝勒医学院吴二喜团队证实同时改善运动与胃肠症状

04

重磅综述！华中科技大学同济医学院附属协和医院吴杰/夏家红团队系统阐述CD4+CTLs细胞——起源、生物学功能、相关疾病与治疗靶点

05

突破血脑屏障！中国科学院动物研究所李伟/胡宝洋/周琪团队Cell发文开发新型靶向蛋白降解新技术，高效清除阿尔茨海默病致病蛋白

06

突破性研究！上海交通大学医学院附属第六人民医院贾伟/郑晓皎团队揭示高糖饮食如何通过肠道菌群加速脂肪肝恶化，开发工程益生菌

点击查看更多热门内容

本文来自网友投稿或网络内容，如有侵犯您的权益请联系我们删除，联系邮箱：wyl860211@qq.com 。

南京理工大学公共事务学院社会学学科2026年度专任教师招聘公告

南京的烟火气

最新文章

随机文章

基本 文件 流程 错误 SQL 调试
  1. 请求信息 : 2026-05-12 11:32:25 HTTP/2.0 GET : https://b.460.net.cn/a/550284.html
  2. 运行时间 : 0.105837s [ 吞吐率：9.45req/s ] 内存消耗：4,470.30kb 文件加载：140
  3. 缓存信息 : 0 reads,0 writes
  4. 会话信息 : SESSION_ID=4899136930b3b3b6a455df29fac26948
  1. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/public/index.php ( 0.79 KB )
  2. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/autoload.php ( 0.17 KB )
  3. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/composer/autoload_real.php ( 2.49 KB )
  4. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/composer/platform_check.php ( 0.90 KB )
  5. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/composer/ClassLoader.php ( 14.03 KB )
  6. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/composer/autoload_static.php ( 4.90 KB )
  7. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-helper/src/helper.php ( 8.34 KB )
  8. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-validate/src/helper.php ( 2.19 KB )
  9. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/helper.php ( 1.47 KB )
  10. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/stubs/load_stubs.php ( 0.16 KB )
  11. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Exception.php ( 1.69 KB )
  12. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-container/src/Facade.php ( 2.71 KB )
  13. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/symfony/deprecation-contracts/function.php ( 0.99 KB )
  14. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/symfony/polyfill-mbstring/bootstrap.php ( 8.26 KB )
  15. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/symfony/polyfill-mbstring/bootstrap80.php ( 9.78 KB )
  16. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/symfony/var-dumper/Resources/functions/dump.php ( 1.49 KB )
  17. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-dumper/src/helper.php ( 0.18 KB )
  18. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/symfony/var-dumper/VarDumper.php ( 4.30 KB )
  19. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/App.php ( 15.30 KB )
  20. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-container/src/Container.php ( 15.76 KB )
  21. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/psr/container/src/ContainerInterface.php ( 1.02 KB )
  22. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/provider.php ( 0.19 KB )
  23. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Http.php ( 6.04 KB )
  24. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-helper/src/helper/Str.php ( 7.29 KB )
  25. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Env.php ( 4.68 KB )
  26. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/common.php ( 0.03 KB )
  27. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/helper.php ( 18.78 KB )
  28. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Config.php ( 5.54 KB )
  29. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/app.php ( 0.95 KB )
  30. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/cache.php ( 0.78 KB )
  31. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/console.php ( 0.23 KB )
  32. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/cookie.php ( 0.56 KB )
  33. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/database.php ( 2.47 KB )
  34. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/facade/Env.php ( 1.67 KB )
  35. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/filesystem.php ( 0.61 KB )
  36. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/lang.php ( 0.91 KB )
  37. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/log.php ( 1.35 KB )
  38. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/middleware.php ( 0.19 KB )
  39. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/route.php ( 1.89 KB )
  40. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/session.php ( 0.57 KB )
  41. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/trace.php ( 0.34 KB )
  42. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/config/view.php ( 0.82 KB )
  43. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/event.php ( 0.25 KB )
  44. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Event.php ( 7.67 KB )
  45. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/service.php ( 0.13 KB )
  46. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/AppService.php ( 0.26 KB )
  47. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Service.php ( 1.64 KB )
  48. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Lang.php ( 7.35 KB )
  49. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/lang/zh-cn.php ( 13.70 KB )
  50. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/initializer/Error.php ( 3.31 KB )
  51. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/initializer/RegisterService.php ( 1.33 KB )
  52. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/services.php ( 0.14 KB )
  53. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/service/PaginatorService.php ( 1.52 KB )
  54. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/service/ValidateService.php ( 0.99 KB )
  55. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/service/ModelService.php ( 2.04 KB )
  56. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-trace/src/Service.php ( 0.77 KB )
  57. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Middleware.php ( 6.72 KB )
  58. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/initializer/BootService.php ( 0.77 KB )
  59. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/Paginator.php ( 11.86 KB )
  60. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-validate/src/Validate.php ( 63.20 KB )
  61. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/Model.php ( 23.55 KB )
  62. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/model/concern/Attribute.php ( 21.05 KB )
  63. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/model/concern/AutoWriteData.php ( 4.21 KB )
  64. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/model/concern/Conversion.php ( 6.44 KB )
  65. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/model/concern/DbConnect.php ( 5.16 KB )
  66. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/model/concern/ModelEvent.php ( 2.33 KB )
  67. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/model/concern/RelationShip.php ( 28.29 KB )
  68. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-helper/src/contract/Arrayable.php ( 0.09 KB )
  69. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-helper/src/contract/Jsonable.php ( 0.13 KB )
  70. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/model/contract/Modelable.php ( 0.09 KB )
  71. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Db.php ( 2.88 KB )
  72. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/DbManager.php ( 8.52 KB )
  73. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Log.php ( 6.28 KB )
  74. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Manager.php ( 3.92 KB )
  75. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/psr/log/src/LoggerTrait.php ( 2.69 KB )
  76. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/psr/log/src/LoggerInterface.php ( 2.71 KB )
  77. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Cache.php ( 4.92 KB )
  78. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/psr/simple-cache/src/CacheInterface.php ( 4.71 KB )
  79. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-helper/src/helper/Arr.php ( 16.63 KB )
  80. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/cache/driver/File.php ( 7.84 KB )
  81. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/cache/Driver.php ( 9.03 KB )
  82. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/contract/CacheHandlerInterface.php ( 1.99 KB )
  83. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/Request.php ( 0.09 KB )
  84. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Request.php ( 55.78 KB )
  85. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/middleware.php ( 0.25 KB )
  86. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Pipeline.php ( 2.61 KB )
  87. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-trace/src/TraceDebug.php ( 3.40 KB )
  88. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/middleware/SessionInit.php ( 1.94 KB )
  89. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Session.php ( 1.80 KB )
  90. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/session/driver/File.php ( 6.27 KB )
  91. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/contract/SessionHandlerInterface.php ( 0.87 KB )
  92. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/session/Store.php ( 7.12 KB )
  93. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Route.php ( 23.73 KB )
  94. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/route/RuleName.php ( 5.75 KB )
  95. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/route/Domain.php ( 2.53 KB )
  96. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/route/RuleGroup.php ( 22.43 KB )
  97. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/route/Rule.php ( 26.95 KB )
  98. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/route/RuleItem.php ( 9.78 KB )
  99. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/route/app.php ( 1.72 KB )
  100. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/facade/Route.php ( 4.70 KB )
  101. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/route/dispatch/Controller.php ( 4.74 KB )
  102. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/route/Dispatch.php ( 10.44 KB )
  103. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/controller/Index.php ( 4.81 KB )
  104. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/app/BaseController.php ( 2.05 KB )
  105. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/facade/Db.php ( 0.93 KB )
  106. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/connector/Mysql.php ( 5.44 KB )
  107. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/PDOConnection.php ( 52.47 KB )
  108. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/Connection.php ( 8.39 KB )
  109. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/ConnectionInterface.php ( 4.57 KB )
  110. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/builder/Mysql.php ( 16.58 KB )
  111. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/Builder.php ( 24.06 KB )
  112. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/BaseBuilder.php ( 27.50 KB )
  113. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/Query.php ( 15.71 KB )
  114. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/BaseQuery.php ( 45.13 KB )
  115. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/TimeFieldQuery.php ( 7.43 KB )
  116. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/AggregateQuery.php ( 3.26 KB )
  117. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/ModelRelationQuery.php ( 20.07 KB )
  118. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/ParamsBind.php ( 3.66 KB )
  119. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/ResultOperation.php ( 7.01 KB )
  120. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/WhereQuery.php ( 19.37 KB )
  121. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/JoinAndViewQuery.php ( 7.11 KB )
  122. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/TableFieldInfo.php ( 2.63 KB )
  123. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-orm/src/db/concern/Transaction.php ( 2.77 KB )
  124. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/log/driver/File.php ( 5.96 KB )
  125. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/contract/LogHandlerInterface.php ( 0.86 KB )
  126. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/log/Channel.php ( 3.89 KB )
  127. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/event/LogRecord.php ( 1.02 KB )
  128. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-helper/src/Collection.php ( 16.47 KB )
  129. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/facade/View.php ( 1.70 KB )
  130. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/View.php ( 4.39 KB )
  131. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Response.php ( 8.81 KB )
  132. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/response/View.php ( 3.29 KB )
  133. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/Cookie.php ( 6.06 KB )
  134. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-view/src/Think.php ( 8.38 KB )
  135. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/framework/src/think/contract/TemplateHandlerInterface.php ( 1.60 KB )
  136. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-template/src/Template.php ( 46.61 KB )
  137. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-template/src/template/driver/File.php ( 2.41 KB )
  138. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-template/src/template/contract/DriverInterface.php ( 0.86 KB )
  139. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/runtime/temp/b35eef690f41e64ad9e1c098cfc7d3bc.php ( 11.98 KB )
  140. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-trace/src/Html.php ( 4.42 KB )
  1. CONNECT:[ UseTime:0.000706s ] mysql:host=127.0.0.1;port=3306;dbname=b460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000827s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000289s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000319s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000535s ]
  6. SELECT * FROM `set` [ RunTime:0.000204s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000531s ]
  8. SELECT * FROM `article` WHERE `id` = 550284 LIMIT 1 [ RunTime:0.000595s ]
  9. UPDATE `article` SET `lasttime` = 1778556745 WHERE `id` = 550284 [ RunTime:0.009346s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000416s ]
  11. SELECT * FROM `article` WHERE `id` < 550284 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000523s ]
  12. SELECT * FROM `article` WHERE `id` > 550284 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000697s ]
  13. SELECT * FROM `article` WHERE `id` < 550284 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000870s ]
  14. SELECT * FROM `article` WHERE `id` < 550284 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.010724s ]
  15. SELECT * FROM `article` WHERE `id` < 550284 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.008854s ]
0.107526s