当前位置：首页>南京>本科毕业于南京农业大学,硕士毕业于中国科学院,博士毕业于清华大学,中国农大副教授以

本科毕业于南京农业大学,硕士毕业于中国科学院,博士毕业于清华大学,中国农大副教授以

  • 2026-04-17 12:41:58
本科毕业于南京农业大学,硕士毕业于中国科学院,博士毕业于清华大学,中国农大副教授以

近日，中国农业大学刘俊峰/王冬立团队在JIPB期刊上发表题为“Gluing rice E3 ligase and pathogen effector for disease control”的文章。中国农业大学植物保护学院博士后常永旗和硕士生周丽丽为该论文共同第一作者, 中国农业大学植物保护学院刘俊峰教授和王冬立副教授为该论文共同通讯作者。

该研究基于水稻——稻瘟菌的互作系统。APIP6是一种水稻胞内的E3泛素连接酶，正调控水稻对稻瘟菌的免疫。AVR-PikC是一种在稻瘟菌生理小种中广泛存在的效应蛋白、可进入水稻细胞，但目前尚未发现可识别该蛋白的免疫受体。该研究通过DNA编码的化合物库，筛选到小分子B93。体外的表面等离子共振和pull-down实验表明，B93可同时与APIP6-RING（APIP6的RING结构域）和AVR-PikC互作，并可介导两种蛋白形成复合物；体内的co-IP和水稻接种实验表明，B93可介导AVR-PikC被蛋白酶体降解，且能抑制含有AVR-PikC基因的稻瘟菌对含有APIP6基因的水稻的致病力。

分子胶B93可介导AVR-PikC被泛素化降解

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  1. CONNECT:[ UseTime:0.000346s ] mysql:host=127.0.0.1;port=3306;dbname=b460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000630s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000260s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000287s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000667s ]
  6. SELECT * FROM `set` [ RunTime:0.000280s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000714s ]
  8. SELECT * FROM `article` WHERE `id` = 496120 LIMIT 1 [ RunTime:0.000683s ]
  9. UPDATE `article` SET `lasttime` = 1777080990 WHERE `id` = 496120 [ RunTime:0.000529s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000270s ]
  11. SELECT * FROM `article` WHERE `id` < 496120 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000467s ]
  12. SELECT * FROM `article` WHERE `id` > 496120 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.002268s ]
  13. SELECT * FROM `article` WHERE `id` < 496120 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000729s ]
  14. SELECT * FROM `article` WHERE `id` < 496120 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.002224s ]
  15. SELECT * FROM `article` WHERE `id` < 496120 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.004709s ]
0.080438s