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乳酸化修饰新突破|南京医科大学王学浩教授等团队揭示AARS2是肝细胞癌的主要调节因子和治疗靶点

  • 2026-06-01 12:00:26
乳酸化修饰新突破|南京医科大学王学浩教授等团队揭示AARS2是肝细胞癌的主要调节因子和治疗靶点
糖酵解的副产物乳酸在肿瘤进展中起着重要的调节作用。最近，人们发现乳酸介导的组蛋白乳酸化可以调节下游靶点的表达，从而促进肿瘤发生、侵袭和转移。肝细胞癌（HCC）是全球最常见的癌症之一，由于诊断困难和治疗耐药性导致其死亡率居高不下。乳酸代谢与蛋白质乳酰化在HCC进展中发挥关键作用，但其调控机制尚不完全清楚。

2026年5月，南京医科大学研究团队在GUT杂志上发表了题为“Landscape screening identifies the lactate-modifying enzyme AARS2 as a master regulator and therapeutic target in hepatocellular carcinoma”的研究论文。

本研究旨在通过整合多组学数据，阐明乳酸代谢与蛋白质乳酰化如何促进肝细胞癌（HCC）的恶性进展，识别关键调控因子，并探索针对该通路的治疗策略。AARS2被确认为通过乳酸化修饰连接乳酸代谢与肝细胞癌（HCC）进展的关键调节因子。抑制剂苦参碱A可阻断AARS2与AP-2γ的相互作用，当以沸石咪唑酯骨架-8纳米载体递送时，展现出更优的肝脏靶向性、强大的抗肿瘤活性及与PD-1阻断的协同作用，为肝细胞癌精准治疗提供了新的战略途径。AARS2通过乳酸化将乳酸代谢与HCC进展联系起来。Kukoamine是一种靶向该轴的纳米疗法，与免疫疗法具有协同作用，推进了精准肿瘤学的前景。

声明：本文整理参考文献：Gut. 2026 May 11:gutjnl-2025-337330. doi: 10.1136/gutjnl-2025-337330.如有侵权请联系后台删除，欢迎交流学习，转载需联系后台。

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  139. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/runtime/temp/b35eef690f41e64ad9e1c098cfc7d3bc.php ( 11.98 KB )
  140. /yingpanguazai/ssd/ssd1/www/b.460.net.cn/vendor/topthink/think-trace/src/Html.php ( 4.42 KB )
  1. CONNECT:[ UseTime:0.001077s ] mysql:host=127.0.0.1;port=3306;dbname=b460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.001640s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000720s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.026693s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.001472s ]
  6. SELECT * FROM `set` [ RunTime:0.000642s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.001541s ]
  8. SELECT * FROM `article` WHERE `id` = 562218 LIMIT 1 [ RunTime:0.003592s ]
  9. UPDATE `article` SET `lasttime` = 1780587487 WHERE `id` = 562218 [ RunTime:0.048626s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 65 LIMIT 1 [ RunTime:0.000721s ]
  11. SELECT * FROM `article` WHERE `id` < 562218 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.001251s ]
  12. SELECT * FROM `article` WHERE `id` > 562218 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.003016s ]
  13. SELECT * FROM `article` WHERE `id` < 562218 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.002766s ]
  14. SELECT * FROM `article` WHERE `id` < 562218 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.020351s ]
  15. SELECT * FROM `article` WHERE `id` < 562218 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.002033s ]
0.208451s